Patente US 20120177566 A1

Membran resident peptide in Anti Cancer peptides causes tumo cell necrosis rather than apoptosis of cancer cells

Abstract

An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell; and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form.

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