Papers and Studies on PNC-27

2014 Annals of Clinical & Laboratory Study

The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.

2010 Journal for Cancer Research Study

MDM2 protein variants expression in the plasma membrane of cancer cells: A target for anticancer peptide PNC-27

2010 Cancer Chemotherapy Pharmacology Study

The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.

2009 National Academy of Science Study

Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes

2006 International Journal of Cancer Study

We have found that this peptide induces necrosis, but not apoptosis, of a variety of human tumor cell lines, including several with homozygous deletion of p53, and a ras-transformed rat acinar pancreatic carcinoma cell line, BMRPA1. Tuc3.

2001 National Academy of Science Study

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells