2010 Cancer Chemotherapy Pharmacology Study

The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.

Abstract

PNC-27, a peptide that contains an HDM-2-binding domain from p53 attached to a membrane-penetrating peptide on its carboxyl terminal end, is cytotoxic to cancer, but not normal, cells. It forms transmembrane pores in the cancer cell membrane. Our purpose is to determine if the whole peptide or critical fragments induce pore formation in cancer cells.

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